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The study protocol was approved by the relevant ethics committee, and all participants provided written informed consent before the commencement of any study-related assessments or procedures

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NAC also protects against mitochondrial dysfunction [50, 51, 69], a key factor in acetaminophen-induced liver injury [52]

Generation of H 2 O 2 by mitochondria and chloroplasts had been reported by Mehler (1951) but it was assumed that H 2 O 2 formation from O 2 was direct and that the molecule would be removed by enzymes such as catalases, which are now not considered to be found in these organelles

Iron reduces M1 macrophage polarization in raw264.7 macrophages associated with inhibition of stat1

Though transcriptomic signatures suggest potential involvement of ATP-consuming futile lipid cycling, this remains speculative