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Description

GLP-1R agonist analogues with turn-promoting -amino acids are more active than those with helix-promoting -amino acids at the fourth position Non-traditional substitutions can yield GLP-1 analogues that show distinctive behavior and these might also provide insight into agonist conformation

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Food and Drug Administration (FDA): Ozempic (semaglutide) Injection Prescribing Information National Institutes of Health (NIH): Gastrointestinal Side Effects of GLP-1 Receptor Agonists and Clinical Management The New England Journal of Medicine (NEJM): Effects of Semaglutide on Chronic Kidney Disease Progression in Patients with Type 2 Diabetes (The FLOW Trial) American Diabetes Association (ADA): Standards of Care in DiabetesMetabolic Strategies and Renal Safety Profile of Incretin-Based Therapies National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): Understanding Acute Kidney Injury: Causes, Risks, and Fluid Balance Protocols

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