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Rapid weight reduction can signal energy deficit to the hypothalamus, potentially suppressing gonadotropin-releasing hormone (GnRH) pulsatility

This is normal and typically subsides within minutes

Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway

In individuals with obesity or metabolic dysfunction, amylin signaling may be impaired