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American Academy of Dermatology

Anyone pregnant or breastfeeding Anyone with a known sensitivity to NAD+ or its components (niacin, nicotinic acid) Anyone with active cancer (caution for those with a prior history and/or a strong family history of cancer) Anyone with severe cardiovascular disease (unstable hypertension, heart failure, arrhythmias) What does the dosing schedule look like

Estrogen moderates blood pressure through three key mechanisms: dilation of blood vessels, inhibition of the renin-angiotensin system in the kidneys and moderation of SNS stimulation

References National Institutes of Health

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Both steps fail more often with age