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These symptoms can lead to reduced fluid intake and increased fluid loss, both of which concentrate the urine and may increase the risk of crystal formation and kidney stone development

Moreover, non-musculoskeletal and non-cutaneous manifestations may be associated with PsO and PsA, such as uveitis, inflammatory bowel disease, and other comorbidities, including obesity and metabolic syndrome, type 2 diabetes mellitus and cardiovascular disease 2

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Additionally, the deletion of FATP4 in bone marrow-derived macrophages and Kupffer cells leads to an increased pro-inflammatory response and induces hepatic fibrosis in HFD-fed female mutants

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F., Boonpheng, B., Phemister, J., Hidalgo, J