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The medication itself hasn't been confirmed as the direct cause

Strains like Akkermansia have been linked to improved metabolic health, better insulin sensitivity, and reduced inflammationall key pieces of sustainable weight management

Disruption of the MC4R pathway, via biallelic mutations in POMC, PCSK1, or LEPR, impairs satiety signaling

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It slows gastric emptying and promotes insulin release in response to food intake, helping reduce food cravings and calorie intake as part of a comprehensive weight loss plan