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The results indicated that GSTM2 regulated SREBF1 and PLIN2 expression by affecting ASK1 activity

These findings underscore the complexity of macrophage polarization beyond the traditional M1/M2 dichotomy, revealing that distinct factors, such as IL-4, drive specific gene expression programs within macrophage subsets that have unique immunosuppressive functions in ovarian cancer ( Collectively, these findings underscore the complex interplay between chemokines, cytokines, and macrophages in ovarian cancer