hengrui glp-1 💊 ORAL UPDATE 💊 Kailera/Hengrui's HRS-7535 showed 9.8% weight loss in a 44-week Phase 3 trial in China. 🇨🇳 While effective and free of hepatotoxicity, high rates of nausea (70%) and Hengrui's GLP-1/GIP agonist posts 18%

Peptides are essentially short (40 or fewer) chains of amino acids, which are the building blocks of proteins

This was corroborated by observations of embryonic lethality in mouse and Caenorhabditis elegans models, with oxidative stress damage shown to be the underlying cause (31)

When any large caloric deficit drives rapid weight loss, a portion of what comes off is lean mass muscle, connective tissue, organ mass, and the water they hold alongside the fat

The trial enrolled 338 adults and tested doses from 1mg to 12mg weekly over 48 weeks

In this study, OCA can also significantly reduce the content of TG and hydroxyproline in the liver tissue of the model mice

It belongs to Malignant|invasive carcinoma but has a very low tendency to metastasize