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Author Contributions Concept and design: Eunhee Choi Acquisition, analysis, or interpretation of data: Eunhee Choi, Laverne Yip, Krishna Kishore Anna, Gabriela Galicia Garcia, Maria F

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( Nature Chemical Biology , 2009) delivered the first balanced synthetic triple agonist in rodents, demonstrating that a single molecule could outperform each mono-agonist in weight efficacy without sacrificing glycemic control