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When a biopsy showed the dark lesion was, indeed, cancerous, doctors removed not only the gums but also parts of the man's upper jaw, according to the case report, published Wednesday in The New England Journal of Medicine

It is an investigational compound presented here for research and educational purposes only and is not approved for general human use

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However, significant translational barriers remain: no human pharmacokinetic data, high synthesis cost, unknown long-term safety, and the absence of clinical trials

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