Pharmaceutical Research, 16 , 1412-1416
Others are included in the synthesis and activation of thyroid hormones, e.g., iodothyronine deiodinase (DIO) 13, synthesis of selenoproteins, e.g., selenophosphate synthetase 2 (SPS2/SEPHS2), or transport of Se (e.g., selenoprotein P) (39, 40)
Chronic GLP-1 use in humans has recently been reported to cause expansion of both exocrine and endocrine pancreas and led to concerns about its unattended proliferative effects in these pancreatic tissues
Practical implication: the proposed rule closes one major access pathway (503B industrial-scale compounding) while leaving the other (503A patient-specific compounding) operational under separate regulatory standards
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Restoring mortality data in the FOURIER cardiovascular outcomes trial of evolocumab in patients with cardiovascular disease: a reanalysis based on regulatory data