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Being a potential potent inhibitor of LRRK2 kinase activity with low risk for off-target side effects, Vit B12 supplementation in patients with PD (PwPD) seems appealing and encourages future clinical trials to investigate this potent effect as such evidence remains restrained to animal models (Green and Christine 2019) (Fig

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This study also showed that higenamine affects histamine one-induced changes in serine/threonine kinase 1 (AKT1), EGFR, c-Jun, iNOS, and JAK2 (Wei et al., 2021)

Welsh and Smith, 1993)