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Diabetes Obes Metab (2013) 15(8):73749

As the primary source of reducing equivalents, NADPH is primarily produced by glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase in the pentose phosphate pathway (PPP)

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Lead poisoning among young children in Russia: Concurrent evaluation of childhood lead exposure in Ekaterinburg, Krasnouralsk, and Volgograd

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Pharmacologic activation of this pathway by metformin amplifies Treg populations (104), while glycolysis inhibition with 2-deoxyglucose (2-DG) shifts metabolism toward FAO, thereby promoting a phenotypic switch from Th17 to Treg cells ( FAO-driven OXPHOS is necessary for Treg cells to continue their suppressive role (105)