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Additionally, by reducing the expression of Smad1 and Smad5, Smurf1 inhibits the TGF-/BMP signaling pathway, promotes cell proliferation, and is crucial for the development of renal tissue[108]

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Excess intracellular iron catalyzes Fenton reactions, generating reactive oxygen species (ROS) that oxidize polyunsaturated fatty acids (PUFAs) in membranes [88], resulting in membrane rupture and cell death (Fig

4 Diabetes and high blood pressure are the leading causes of CKD, accounting for 75% of new cases in the United States