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JAMA 327 , 138 (2022)

For some local diseases related to the skin or nervous system, such as skin nerve injury, local neuropathy, etc., cream formulations can directly deliver drugs to the affected area, increase the concentration of drugs locally, and enhance the therapeutic effect

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Coupling with drugs, fluorescent tracers or various targeting molecules can significantly change the physico-chemical properties and the intracellular fate of the nanocarriers [28, 51]