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Currently, the pathogenesis of kidney stones is mainly based on the Randall plaque doctrine and the Randall plug doctrine [99]

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Sequence degeneracy involves mismatches ranging from 1 to 3 base pairs per 15-mer ARE, a higher GC content in the 3 bp spacer between hexamers in imperfect AREs, and over two-thirds of AREs are recognized to consist of half sites only, with a minority making up canonical 15mer AREs [53, 56]

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