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showed certain -Gal A mutations, such as missense in Fabry Disease cause ER retention and UPR activation, suggesting a new pathogenic pathway (73)

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Lipid Peroxidation Inhibitors (e.g., Ferrostatin-1, Liproxstatin-1, Vitamin E) act as radical-trapping antioxidants, terminating lipid peroxidation chain reactions

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Viral triggers and reactivation As in other chronic diseases, ME/CFS involves an asymptomatic predisposition stage, then a prodromal stage, followed by symptomatic disease (59)