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Science Advances , 7 (2)

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First, it's important to remember that Victoza is not technically a weight loss medication

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Topiramate is used for weight loss and is also used off-label and endorsed by the American Psychiatric Association as a second-line treatment for AUD [25]

Specifically, GLP-1RAs downregulate activation of VCAM1, the intracellular adhesion molecule-1 (ICAM-1) and plasminogen activator inhibitor type 1 (PAI-1) in endothelial cells [57]