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Among the various mechanisms proposed, the gut microbiota has been reported to modulate the expression and secretion of glucagon-like peptide hormones from enteroendocrine cells 27,61

coli GCL also functions as a monomeric protein (Hibi et al., Biochemical studies of the GCL from plants revealed that these proteins are regulated by redox environment through a mechanism that differs from the heterodimeric enzymes (Jez et al., Arabidopsis GCL showed that the enzyme was inactivated by buthionine sulfoximine, a potent inhibitor of mammalian GCL, and used a random ter-reactant kinetic mechanism with a preferred order of binding for catalysis (Jez et al., 2+ , orients the glutamate -carboxylate for attack on the -phosphate of ATP, which is positioned by a second Mg 2+ and an active site lysine

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Nat Commun 5:3611 Garzya G, Corallo D, Fiore A, Lecciso G, Petrelli G, Zotti C (1990) Evaluation of the effects of l-acetylcarnitine on senile patients suffering from depression

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