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Flagellin and poly(dA: dT) were used as activators for NLRC4 and AIM2, respectively, both of which significantly increased IL-1 release (Supplementary Fig

Thrombus-derived exosomes (TEs) induced pronounced ferritinophagy in cardiomyocytes, evidenced by increased autophagosomes, ROS, apoptosis, and iron overload, with these effects ameliorated by the ferroptosis inhibitor Fer-1

Given the limited availability of pediatric data for dual and triple agonists, evidence from adult clinical trials was included where relevant to provide mechanistic insights and contextual understanding

Furthermore, glucagon receptor agonism is being investigated for the treatment of NAFLD due to its appetite and food intake-reducing effects, as well as its ability to increase lipid oxidation and thermogenesis

If you take critical oral medications, ask your clinician whether spacing from meals/probiotics is sensible