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Clinical trials show that patients combining medication with diet and exercise modifications achieve better outcomes than those relying on medication alone

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In patients with treatment-resistant depression, naltrexone 50 mg blocked the antidepressant but not the dissociative effects of KET, suggesting that the opioid system may also be required for KET antidepressant activities (Williams et al., 2018)

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Russell-Aulet M, Jaffe CA, DeMott-Friberg R, Barkan AL