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A 2021 randomized trial found tesamorelin improved verbal memory and executive function in older adults with mild cognitive impairment the first GHRH analogue to demonstrate cognitive improvement in a controlled trial

Its underlying mechanisms are multifaceted, encompassing genetic variations, environmental influences, cerebral artery constriction, abnormalities in monoamine neurotransmitters, oxidative stress, mitochondrial disturbances, the involvement of calcitonin gene-related peptide (CGRP), neurogenic inflammation, and broader neuroinflammation (6)

Synonyms: GSH-EE, GSH ethyl ester, GSH monoethyl ester

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