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Quick Answer: GLP-1 receptor agonists improve fatty liver disease by reducing liver fat content, improving liver enzymes, and achieving NASH resolution in clinical trials, primarily through weight loss and enhanced insulin sensitivity

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CAFs-induced ECM remodeling results in increased tissue stiffness and the activation of mechanotransduction signaling pathways, such as integrin-FAK and YAP/TAZ signaling, thereby conferring increased malignancy to tumors (121)