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It tends to occur during early use and may diminish with dose adjustment

It can lead to a cascade of health issues, affecting not just the liver but also the immune system

Patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 should avoid GLP-1 drugs entirely, and adding a DPP-4 inhibitor does not change this contraindication

Kooy A et al (2009): Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus

The cell membrane was genetically edited to highly express macrophage signal regulatory protein (MSIRP), which enhanced binding to CD47 on CRC cell surfaces, blocked the dont eat me signal, and promoted macrophage phagocytosis

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