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DHEA has important metabolic, immune-modulating, and neuroprotective effects and is also a precursor for testosterone and estrogens

Optimization was performed by comparing the expression levels of fusion proteins and evaluating their agonistic activity towards GLP-1R, antagonistic activity towards GIPR, pharmacokinetic properties, as well as changes in body weight and blood glucose levels

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10.1016/j.ctrv.2022.102429 [DOI] [PMC free article] [PubMed] [Google Scholar] Song Y., Challa S