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16 weeks 5 vials Lower vial count but larger draw volumes per dose 26 weeks 7 vials Standard Phase 2 duration 32 weeks 8 vials Phase 2 T2D study duration 68 weeks 17 vials Long-cycle planning matches REDEFINE 1 and 2 Insulin Syringes (U-100, 1 mL) One syringe per weekly injection

Data availability Coordinates and structure factors for EV-F3 under conditions (1), (2) and (3) are deposited in the PDB with accession codes 6T4C, 6T40 and 6T48, respectively

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Higher doses may cause GI upset or a fishy odor

PubMed Wchter S, Vogt M, Kreis R, Boesch C, Bigler P, Hoppeler H, Krhenbhl S

Following the guidance provided before and after treatment can help support the best possible experience