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moderate certainty), but may result in little to no harm from other adverse events, such as hiccups, gastrointestinal disturbances, skin irritation from patches, throat irritation, or runny nose.43 Varenicline results in small harms from increases in nausea (32 RCTs, n = 14 963

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14 This approach is suitable for patients who smoke within one hour of waking (most reliable indicator of dependence) and those who smoke ten or more cigarettes per day

doi:10.1136/tobaccocontrol-2018-054333

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