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Healthy never smokers, e-cig users, cigarette smokers and THC vapers (including medical marijuana) between ages 18-45 are eligible to participate in the study

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The carcinogenic effect is based on reactive metabolites of nitrosamines in the metabolism, which react with the genetic material DNA, damaging it and triggering tumors

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A 2013 direct mail piece from American Spirit also sought to appeal to the environmentally conscious consumer, referring to a new paper liner inside the pack as more eco-friendly than the previous foil liner