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Consistent with the broad action of the incretins in the brain and the periphery, the receptors for GIP and GLP-1 receptors show widespread distribution that includes also hypothalamic and hindbrain regions implicated in regulation of body weight and food intake [52,53,54,55]

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2 Seedling hardening: Durian seedlings have soft and tender branches and leaves, and their root systems have weak growth capacity during the seedling stage, resulting in low transplant survival rates

In another phase 2 trial, a 2-week course of treatment with teplizumab among patients who had two or more antibodies positive, family history of T1D, and IGT showed that the progression to stage 3 diabetes could be delayed for 2 years [47]