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doi: 10.3389/fcell.2025.1685252 Received 13 August 2025 Accepted 08 October 2025 Published 23 October 2025 Volume 13 - 2025 Edited by Hilary Ann Coller, University of California, Los Angeles, United States Reviewed by Jianyun Liu, Indiana University Bloomington, Bloomington, United States Ruoxi Zhang, University of Texas Southwestern Medical Center, United States Updates Copyright 2025 Peng, Zhang, Ma, Zhang, Guan and Yu

Glyoxalase (Glo) performs conjugation of GSH with the glycolysis byproduct methylglyoxal to form (S)-lactoylglutathione (Figure 2)

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