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This study further strengthens the case for using GLP-1 agonists in obese patients with HFpEF, a type of heart failure that is associated with significant morbidity and mortality, said Pooja Prasad, MD, an assistant clinical professor in the Department of Advanced Heart Failure & Transplant Cardiology at the University of California San Francisco
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Similarly, in PD, early disease stages are characterized by oxidative stress and heightened proinflammatory responses that exacerbate nigrostriatal degeneration,111,112 with Proinflammatory mediators have also been identified in the substantia nigra of postmortem PD brains.113 Systemic inflammation plays a central role in the pathophysiology of hyperinsulinemia, insulin resistance, and T2DM
The neuroprotective benefit may stem from GLP-1s role in insulin signaling within the brain, where insulin resistance is a recognized early feature of Alzheimers pathophysiology
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