Retrieved from Jeanmonod R, Jeanmonod D
Medium-chain fatty acids (MCFAs) (C8C10) bind the PPAR ligand binding domain in vitro, causing full inhibition of phosphorylation of PPAR by cyclin-dependent kinase 5 (cdk5) and reversal of IR in adipose tissue

Conclusions N/A Keywords Oligometastatic clear cell renal cell carcinoma (ccRCC), Stereotactic body radiation therapy (SBRT), Dual checkpoint blockade (PD-1/LAG-3), Cemiplimab and Fianlimab DOD CDMRP Funding no" IO biomarker Metastases P2 data Clear Cell Renal Cell Carcinoma Renal Cell Carcinoma LAG3 July 17, 2026 Long-Term Overall Survival (OS) with Fianlimab (Fian) plus Cemiplimab (Cemi) in Advanced Melanoma (aMel): Survival Follow-Up of a Phase 1 Study (ESMO 2026) - No abstract available Clinical Metastases P1 data Melanoma Oncology Solid Tumor July 17, 2026 A Study Comparing Two Immunotherapy Options for Human Papillomavirus Positive HPV-Positive Head and Neck Cancer After Treatment (clinicaltrials.gov) - P2 | N=68 | Recruiting | Sponsor: University of Chicago | Not yet recruiting Recruiting | Initiation date: Dec 2026 Jun 2026 Enrollment open Minimal residual disease Trial initiation date Head and Neck Cancer Oncology Oropharyngeal Cancer Solid Tumor Squamous Cell Carcinoma of Head and Neck July 15, 2026 HARMONY LUNG-2: A Trial to Learn How the Combination of Fianlimab With Cemiplimab and Chemotherapy Works Compared With Cemiplimab and Chemotherapy for Treating Adult Patients With Advanced Non-small Cell Lung Cancer (clinicaltrials.gov) - P2/3 | N=160 | Active, not recruiting | Sponsor: Regeneron Pharmaceuticals | N=950 160 Biomarker Enrollment change IO biomarker Lung Cancer Non Small Cell Lung Cancer Oncology Solid Tumor PD-L1 July 07, 2026 A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery (clinicaltrials.gov) - P3 | N=1564 | Active, not recruiting | Sponsor: Regeneron Pharmaceuticals | Trial primary completion date: May 2028 Jul 2026 Trial primary completion date Melanoma Oncology Solid Tumor July 03, 2026 Androgen Deprivation, With or Without pTVG-AR, and With or Without T-Cell Checkpoint Blockade, in Patients With Newly Diagnosed, High-Risk Prostate Cancer (clinicaltrials.gov) - P1/2 | N=57 | Active, not recruiting | Sponsor: University of Wisconsin, Madison | Recruiting Active, not recruiting Checkpoint inhibition Enrollment closed Genito-urinary Cancer Oncology Prostate Adenocarcinoma Prostate Cancer Solid Tumor July 03, 2026 HARMONY LUNG-1: A Study to Learn if a Combination of Fianlimab and Cemiplimab Versus Cemiplimab Alone is More Effective for Adult Participants With Advanced Non-Small Cell Lung Cancer (NSCLC) (clinicaltrials.gov) - P2/3 | N=149 | Active, not recruiting | Sponsor: Regeneron Pharmaceuticals | N=850 149 | Trial completion date: Feb 2032 Sep 2027 | Trial primary completion date: Mar 2030 Sep 2027 Enrollment change Monotherapy Trial completion date Trial primary completion date Lung Cancer Non Small Cell Lung Cancer Oncology Solid Tumor PD-L1 July 01, 2026 Capecitabine/Oxaliplatin Chemotherapy and Cemiplimab With or Without Fianlimab or REGN7075 in Locally Advanced Rectal Cancer (clinicaltrials.gov) - P2 | N=66 | Recruiting | Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Not yet recruiting Recruiting Enrollment open Colorectal Cancer Oncology Rectal Adenocarcinoma Rectal Cancer Solid Tumor April 21, 2026 Phase II study of cemiplimab fianlimab following SBRT for oligometastatic clear-cell RCC (LAG-BOOST)

Diabetes is the most common cause of gastroparesis, according to the National Institute of Diabetes and Digestive and Kidney Diseases
By raising muscle carnosine levels, beta-alanine supplementation has been shown to be effective in improving performance during brief, high-intensity exercises
Future evidence may highlight specific populations, not yet covered by guidance, who may benefit from taking them. For food and beverage, this will create challenges as well as opportunities but staying across the science is essential for exploiting them