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That being said, because IGF variants frequently increase permanent lean muscle mass via hyperplasia, your basal metabolic rate (how many calories you burn naturally at rest) is typically elevated permanently, making it easier to stay leaner year-round moving forward

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However, when intestinal barrier damage leads to decreased calcium absorption, the insufficient concentration of blood calcium directly stimulates the parathyroid glands to secrete PTH, liberating calcium at the expense of bone resorption (83)

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10.3389/fphys.2020.00713 48 RaoY.ChenJ.GuoY.JiT.XieP