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Furthermore, in vitro intervention of lactate in Nave CD4 + T cells can promote the differentiation of CD4 + T cells into Treg by increasing mTOR phosphorylation and HIF-1 synthesis, while the addition of lactate uptake inhibitor AZD3965, LDHA inhibitor GSK2837808A, and NADH conversion inhibitor Rotenone can reverse this differentiation (138)

Waxman JA, Sulak PJ and Kuehl TJ: Cystoscopic findings consistent with interstitial cystitis in normal women undergoing tubal ligation

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