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This copper-binding tripeptide activates TGF-beta/SMAD pathway signaling, stimulates collagen I and III synthesis, upregulates TIMP-1 and TIMP-2 to protect collagen from degradation, and modulates gene expression across approximately 4,000 human genes

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55 Together, the combined actions of various disorders in the proximal signaling components leads to impaired glucose metabolism and IR, and a major challenge remains for understanding IR mechanisms regarding how to distinguish the causes from insulin effects or primary defects from their consequences

IQGAP-2: A novel interacting partner for the human colonic thiamin pyrophosphate transporter (hcTPPT)

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