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10.1038/s41467-022-28718-6 461 van GijnJ.KerrR

Lastly, a 2017 review found that some studies reported benefits from ECGC on energy expenditure and fat oxidation when paired with an exercise regimen

Possible side effects are mild and may include slight redness or tenderness at the injection site, which typically resolves within a few hours

For now, access is limited to regulated clinical trials

Mean age-adjusted cognition composite of the NIH Cognition Toolbox Test Battery following administration of l-theanine and l-theaninecaffeine combination were respectively 11.5 and 11.4 points greater than the mean cognition composite score achieved following administration of placebo (p = 0.040, Cohens d = 1.041 and p = 0.041, Cohens d = 1.034 respectively)

However, real-world challenges and limited clinician and public knowledge on nutritional and lifestyle interventions can limit GLP-1 efficacy, equitable results, and cost-effectiveness