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These results indicated that GHK decreases AQP4 expression via miR-146a-3p through the PI3K/Akt pathway (Figure 7)

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The UPLC flow rate was set to 0.3 ml min 1 at 60 C using a gradient elution from 10 to 65% B over the course of 4.0 min

The hypothesis that coffee consumption lowers the risk of DM2 involves several possible mechanisms as its likely effects on obesity and insulin sensitivity, which are important risk factors for DM2 [1]