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This effect may be attributed to its targeting of ADAM17, which facilitates the IL-23/IL-23R/Th17 cell axis [50], or its repression of Ets1 expression [51]

NemethETuttleMSPowelsonJVaughnMBDonovanAWardDMet alHepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

The effect appears to be rapid and sustained, suggesting BPC-157 may act as a potent modulator of the cellular machinery responsible for closing tissue gaps