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The change in HbA1c ranged from 1.87% to 2.59% for various doses of tirzepatide compared to placebo, 1.86% for weekly 1 mg semaglutide in the SURPASS-2 trial, 1.34% for degludec insulin in the SURPASS-3 trial, and 1.44% for glargine insulin in the SURPASS-4 trial [94,95,96] (Figure 7)