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In mammalian cells, glutathione primarily exists in the reduced state at moderate concentrations and in an extremely high proportion, effectively scavenging reactive intermediates produced spontaneously by cells or from external toxic factors, thereby protecting the cells
and accordingly nerve damage appeared in various brain areas, with most prominent damage in corpus callosum, laterodorsal thalamus, nucleus reunions, anterior horn motor neurons, regional heterogeneities which suggest differences in the underlying pathophysiology as it had been previously claimed (72)
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Graphene oxide nanosheets induce mitochondrial fragmentation by cutting through membrane