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Stimulation of muscle resident fibroblasts with this factor increases their collagen and fibronectin production, which results in increased interstitial fibrosis [4143]

This is important for two reasons

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Feeding mice with the KD resulted in a noteworthy decrease in the expression of immune inhibitory receptors (PD-1 and CTLA-4) on CD8 + TILs, as well as a reduction in the expression of inhibitory ligands (CD86 and PD-L1) on cancer cells

This effect is glucose-dependent, meaning it primarily occurs when blood sugar is high, reducing the risk of hypoglycemia (low blood sugar)