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Notably, crosslinking of FcRI by antigen binding to FcRI-associated IgE increases mast cell Hdc mRNA expression and histamine synthesis (57, 58)

Indeed, in pre-clinical studies inhibition of IGF-1R with Linsitinib combined with WEE1 (checkpoint) inhibition led to tumor regression of low replication stress Ewing sarcoma tumors [132]

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Also, the potential affinity of each moiety of the engineered fusion proteins against their specific targets was explored

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