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Effect of MTHFR C677T Genotype on Folate, Homocysteine, and Vitamin B12 Status in Humans

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As an initiating factor, mitochondrial DNA mutations or oxidative damage can disrupt respiratory chain function, leading to energy failure and subsequent organ dysfunction [27]

To the extent viscosity considerations potentially limit the use of a syringe/needle delivery system, thermoreversible gels or post-administration viscosity-enhancing options are also envisioned, as well as alternative delivery systems, including pumps, microinjection devices and the like

The biosynthesis of glutathione (GSH) and the normal function of GPX4 are central to the control of ferroptosis, and the inhibition of GPX4 can increase cellular ferroptosis sensitivity [6, 7]