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Both GIPR and GLP-1R are expressed in overlapping brain regions including the ARC, PVN, and AP

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Under the brand name Zepbound, it's approved to treat obesity, while under the brand name Mounjaro, it's approved to treat type 2 diabetes

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Psychiatry 66, 7080

The peptide retains activity in human gastric juice for more than 24 hours, tolerates pH from 1 to 11, and resists multiple proteolytic enzymes, properties that derive from the high proline content (four of fifteen residues) and the absence of cleavage-prone motifs