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2025;12:e2409329

A standard autopsy was performed, and lungs were harvested as described previously ( 2 as described previously ( For histology studies, the lower lobe of the right lung was fixed in 10% neutral buffered formalin

Target-based drug discovery has become the primary approach in pharmaceutical research and development, where drug targets play a crucial role in guiding the entire process

Homosynaptic plasticity Homosynaptic plasticity is one type of synaptic plasticity

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However, some studies have proven that -arrestin 2 mediates acute rather than chronic opioid tolerance, which indicates that opioid-induced antinociceptive tolerance may even occur without the activation of -arrestin 2 [96], as it should be