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Synthetic hormones, specifically progestins, by an oral route led to the creation of metabolites in the liver which caused an increase in the incidence of breast and uterine cancers

Current oral users commonly cite convenience and a preference to avoid injections as their primary reasons for taking a pill

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Levy DI, Sucher NJ, Lipton SA

The Semaglutide cohort compared with the Non-GLP-1RA anti-obesity medications cohort was older and had a higher prevalence of morbid obesity, T2D and obesity-associated comorbidities, and a lower prevalence of mental disorders and substance use disorders

the additive hypoglycemia risk outweighs any signaling benefit