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Four structural limitations define how the evidence must be interpreted before any application to humans is considered

The chaperone equilibrium hypothesis proposes that NF-B activation may decrease intracellular levels of HSP70, releasing extracellular HSP70 as a pro-inflammatory component, which may be linked to reduced oxidative stress in target cells

The inflammatory component of many chronic conditions deserves special attention

Part B, Neuropsychiatry Genetics : The Official Publication of the International Society of Psychiatric Genetics, 141B(8), 947-56

Its the quiet support player, not the star