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Cancer initiation and progression have been linked to oxidative stress through mechanisms that increase DNA mutations or induce DNA damage, genome instability, and cell proliferation 82

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

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Glutathione synthetase (GSS) is involved in the final step of glutathione production, while glutathione peroxidases (GPXs) help use it to neutralize harmful reactive oxygen species

COCs were inseminated with Control or HyperSperm-treated sperm, and incubated at 37C, 7% CO 2 and 5% O 2

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