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One of the chief pathways involved in neuroinflammation is HMGB1 cue, which plays a key role in the etiopathology of neurodevelopmental diseases, where HMGB1 is triggered by excessive ROS levels (Makris et al

Most mechanistic evidence derives from preclinical models, while human data remain largely associative

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Pottegrd A, Schmidt SAJ, Wallach-Kildemoes H, Srensen HT, Hallas J, Schmidt M (2017) Data resource profile: the Danish national prescription registry