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The peptide has been studied extensively across various organ systems, demonstrating cytoprotective effects in the gastrointestinal tract, liver, pancreas, heart, blood vessels, muscle, tendon, ligament, bone, and nervous system

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doi:10.1016/j.ghir.2014.12.005

The PERK-ATF4 pathway induces the expression of multiple vascular endothelial growth factors, including VEGFA, VEGFB, VEGFC, VEGFD, VEGFF, and placental growth factor, which collectively support endothelial cell survival, neovascularization, and sustained tumor growth

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